5′ isomiR variation is of functional and evolutionary importance
نویسندگان
چکیده
منابع مشابه
5′ isomiR variation is of functional and evolutionary importance
We have sequenced miRNA libraries from human embryonic, neural and foetal mesenchymal stem cells. We report that the majority of miRNA genes encode mature isomers that vary in size by one or more bases at the 3' and/or 5' end of the miRNA. Northern blotting for individual miRNAs showed that the proportions of isomiRs expressed by a single miRNA gene often differ between cell and tissue types. I...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2014
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/gku656